The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

The cyclic imine toxin 20-methyl spirolide G (20-meSPX-G), produced by the toxigenic dinoflagellate Alexandrium ostenfeldii/Alexandrium peruvianum, has been previously reported to contaminate shellfish in various European coastal locations, as revealed by mouse toxicity bioassay. The aim of the pres...

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Bibliographic Details
Main Authors: Aurélie Couesnon, Rómulo Aráoz, Bogdan I. Iorga, Evelyne Benoit, Morgane Reynaud, Denis Servent, Jordi Molgó
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Toxins
Subjects:
dinoflagellate toxin
spirolides
nicotinic acetylcholine receptors
neuromuscular transmission
Xenopus oocytes
nicotinic currents
competition-binding assays
molecular docking
Online Access:http://www.mdpi.com/2072-6651/8/9/249

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http://www.mdpi.com/2072-6651/8/9/249

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