Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling

Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling

Abstract Background The generation of liver organoids recapitulating parenchymal and non-parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases. Although different types of multilineage liver organoids (mLOs) have been generated from human pluripotent stem cells...

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Bibliographic Details
Main Authors: Hyo Jin Kim, Gyeongmin Kim, Kyun Yoo Chi, Hyemin Kim, Yu Jin Jang, Seongyea Jo, Jihun Lee, Youngseok Lee, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Stem Cell Research & Therapy
Subjects:
Liver organoid
Vasculature
Bile duct
Notch
Hepatic stellate cell
Fibrosis
Online Access:https://doi.org/10.1186/s13287-023-03235-5

Internet

https://doi.org/10.1186/s13287-023-03235-5

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