Hexameric helicase G40P unwinds DNA in single base pair steps

Most replicative helicases are hexameric, ring-shaped motor proteins that translocate on and unwind DNA. Despite extensive biochemical and structural investigations, how their translocation activity is utilized chemo-mechanically in DNA unwinding is poorly understood. We examined DNA unwinding by G4...

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Bibliographic Details
Main Authors: Michael Schlierf, Ganggang Wang, Xiaojiang S Chen, Taekjip Ha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/42001