Function and mechanism of TREM2 in bacterial infection.
Triggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011895&type=printable |
| _version_ | 1797349397742223360 |
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| author | Zehua Wu Shiyue Yang Xiangming Fang Qiang Shu Qixing Chen |
| author_facet | Zehua Wu Shiyue Yang Xiangming Fang Qiang Shu Qixing Chen |
| author_sort | Zehua Wu |
| collection | DOAJ |
| description | Triggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-mediated inhibition of inflammation by negatively regulating the Toll-like receptor (TLR) response. We further illustrate the role of TREM2 in restoring organ homeostasis in sepsis and soluble TREM2 (sTREM2) as a diagnostic marker for sepsis-associated encephalopathy (SAE). Finally, we discuss the prospect of TREM2 as an interesting therapeutic target for sepsis. |
| first_indexed | 2024-03-08T12:29:06Z |
| format | Article |
| id | doaj.art-33fcb1f5fffa482a93667b01d0359dec |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-03-08T12:29:06Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-33fcb1f5fffa482a93667b01d0359dec2024-01-22T05:30:45ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-01-01201e101189510.1371/journal.ppat.1011895Function and mechanism of TREM2 in bacterial infection.Zehua WuShiyue YangXiangming FangQiang ShuQixing ChenTriggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-mediated inhibition of inflammation by negatively regulating the Toll-like receptor (TLR) response. We further illustrate the role of TREM2 in restoring organ homeostasis in sepsis and soluble TREM2 (sTREM2) as a diagnostic marker for sepsis-associated encephalopathy (SAE). Finally, we discuss the prospect of TREM2 as an interesting therapeutic target for sepsis.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011895&type=printable |
| spellingShingle | Zehua Wu Shiyue Yang Xiangming Fang Qiang Shu Qixing Chen Function and mechanism of TREM2 in bacterial infection. PLoS Pathogens |
| title | Function and mechanism of TREM2 in bacterial infection. |
| title_full | Function and mechanism of TREM2 in bacterial infection. |
| title_fullStr | Function and mechanism of TREM2 in bacterial infection. |
| title_full_unstemmed | Function and mechanism of TREM2 in bacterial infection. |
| title_short | Function and mechanism of TREM2 in bacterial infection. |
| title_sort | function and mechanism of trem2 in bacterial infection |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011895&type=printable |
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