<sup>68</sup>Ga-Labeled [Leu<sup>13</sup>ψThz<sup>14</sup>]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake

<sup>68</sup>Ga-Labeled [Leu<sup>13</sup>ψThz<sup>14</sup>]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake

The gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled receptor that is overexpressed in many solid cancers and is a promising target for cancer imaging and therapy. However, high pancreas uptake is a major concern in the application of reported GRPR-targeting radiopharmaceuticals, par...

Full description

Bibliographic Details
Main Authors: Lei Wang, Zhengxing Zhang, Helen Merkens, Jutta Zeisler, Chengcheng Zhang, Aron Roxin, Ruiyan Tan, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
gastrin-releasing peptide receptor
positron-emission tomography
gallium-68
pancreas uptake
Online Access:https://www.mdpi.com/1420-3049/27/12/3777

Internet

https://www.mdpi.com/1420-3049/27/12/3777

Similar Items