Screening, Synthesis and Biochemical Characterization of SARS-CoV-2 Protease Inhibitors

Screening, Synthesis and Biochemical Characterization of SARS-CoV-2 Protease Inhibitors

The severe acute respiratory syndrome-causing coronavirus 2 (SARS-CoV-2) papain-like protease (PL<sup>pro</sup>) and main protease (M<sup>pro</sup>) play an important role in viral replication events and are important targets for anti-coronavirus drug discovery. In search of...

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Bibliographic Details
Main Authors: Martynas Bagdonas, Kamilė Čerepenkaitė, Aurelija Mickevičiūtė, Rūta Kananavičiūtė, Birutė Grybaitė, Kazimieras Anusevičius, Audronė Rukšėnaitė, Tautvydas Kojis, Marius Gedgaudas, Vytautas Mickevičius, Daumantas Matulis, Asta Zubrienė, Jurgita Matulienė
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
papain-like protease
main protease
thiazole
disulfide
thermal shift assay
Online Access:https://www.mdpi.com/1422-0067/24/17/13491

Internet

https://www.mdpi.com/1422-0067/24/17/13491

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