Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

Adeno-associated virus (AAV)-based brain gene therapies require precision without off-targeting of unaffected neurons to avoid side effects. The cerebellum and its cell populations, including granule and Purkinje cells, are vulnerable to neurodegeneration; hence, conditions to deliver the therapy to...

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Bibliographic Details
Main Authors: Magdalena Surdyka, Ewelina Jesion, Anna Niewiadomska-Cimicka, Yvon Trottier, Żaneta Kalinowska-Pośka, Maciej Figiel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
adeno-associated virus (AAV)
AAVrh10
AAV-PHP.eB
cerebellum
deep cerebellar nuclei
Purkinje cells
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.947490/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.947490/full

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