Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice

Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice

Abstract Background Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with diabetes, the diabetic environment affected MSCs activity and could impair...

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Bibliographic Details
Main Authors: Xin Meng, Minjuan Zheng, Ming Yu, Wei Bai, Lei Zuo, Xin Bu, Yi Liu, Linying Xia, Jing Hu, Liwen Liu, Jianping Li
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Biological Engineering
Subjects:
CRISPRa
IL-10
BM-MSCs
Myocardial infarction
Diabete
Online Access:http://link.springer.com/article/10.1186/s13036-019-0163-6

Internet

http://link.springer.com/article/10.1186/s13036-019-0163-6

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