Intravenous injection of a novel viral immunotherapy encoding human interleukin-7 in nonhuman primates is safe and increases absolute lymphocyte count

Intravenous injection of a novel viral immunotherapy encoding human interleukin-7 in nonhuman primates is safe and increases absolute lymphocyte count

Persistence of an immunosuppression, affecting both the innate and adaptive arms of the immune system, plays a role in sepsis patients’ morbidity and late mortality pointing to the need for broad and effective immune interventions. MVA-hIL-7-Fc is a non-replicative recombinant Modified Vaccinia viru...

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Bibliographic Details
Main Authors: Charles-Antoine Coupet, Clarisse Dubois, Alexeï Evlachev, Nadine Kehrer, Marie Baldazza, Sam Hofman, Michel Vierboom, Perrine Martin, Geneviève Inchauspe
Format: Article
Language:English
Published: Taylor & Francis Group 2022-11-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
immunotherapy
virotherapy
modified vaccinia virus ankara
interleukin-7
nonhuman primates
pharmacokinetics
immune activation
Online Access:http://dx.doi.org/10.1080/21645515.2022.2133914

Internet

http://dx.doi.org/10.1080/21645515.2022.2133914

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