A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

The presence of dark melanin (eumelanin) within human epidermis represents one of the strongest predictors of low skin cancer risk. Topical rescue of eumelanin synthesis, previously achieved in “redhaired” Mc1r-deficient mice, demonstrated significant protection against UV damage. However, applicati...

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Bibliographic Details
Main Authors: Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
pigmentation
eumelanin
salt-inducible kinase (SIK)
microphthalmia-associated transcription factor (MITF)
topical drug
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306848

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http://www.sciencedirect.com/science/article/pii/S2211124717306848

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