Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

The HIV-1 capsid (CA) protein has emerged as an attractive therapeutic target. However, all inhibitor designs and structural analyses for this essential HIV-1 protein have focused on the clade B HIV-1 (NL4-3) variant. This study creates, overproduces, purifies, and characterizes the CA proteins from...

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Bibliographic Details
Main Authors: Alexej Dick, Megan E. Meuser, Simon Cocklin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/12/5/695