Optimized Replacement T4 and T4+T3 Dosing in Male and Female Hypothyroid Patients With Different BMIs Using a Personalized Mechanistic Model of Thyroid Hormone Regulation Dynamics

Optimized Replacement T4 and T4+T3 Dosing in Male and Female Hypothyroid Patients With Different BMIs Using a Personalized Mechanistic Model of Thyroid Hormone Regulation Dynamics

ObjectiveA personalized simulation tool, p-THYROSIM, was developed (1) to better optimize replacement LT4 and LT4+LT3 dosing for hypothyroid patients, based on individual hormone levels, BMIs, and gender; and (2) to better understand how gender and BMI impact thyroid dynamical regulation over time i...

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Bibliographic Details
Main Authors: Mauricio Cruz-Loya, Benjamin B. Chu, Jacqueline Jonklaas, David F. Schneider, Joseph DiStefano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
simulation
math model
monotherapy
combination hormone therapy
residual thyroid function
p-THYROSIM
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.888429/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.888429/full

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