Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle vaccine broadens antibody responses in mice to cros...

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Bibliographic Details
Main Authors: Seyhan Boyoglu-Barnum, Geoffrey B. Hutchinson, Jeffrey C. Boyington, Syed M. Moin, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, John R. Vaile, Julia Lederhofer, Kizzmekia S. Corbett, Brian E. Fisher, Hadi M. Yassine, Sarah F. Andrews, Michelle C. Crank, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14579-4

Internet

https://doi.org/10.1038/s41467-020-14579-4

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