Formulation and Characterization of Ursodeoxycholic Acid Nanosuspension Based on Bottom-Up Technology and Box–Behnken Design Optimization

Formulation and Characterization of Ursodeoxycholic Acid Nanosuspension Based on Bottom-Up Technology and Box–Behnken Design Optimization

Background: Ursodeoxycholic acid (UDCA) is a therapeutic agent used for the treatment of cholestatic hepatobiliary diseases in pediatric patients. It is a bile acid that presents high lipophilicity, and it belongs to Class II of the Biopharmaceutical Classification System (BCS), which exhibits low w...

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Bibliographic Details
Main Authors: Oriana Boscolo, Sabrina Flor, Leandro Salvo, Cecilia Dobrecky, Christian Höcht, Valeria Tripodi, Marcela Moretton, Silvia Lucangioli
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
nanosuspension
ursodeoxycholic acid
Box–Behnken design
bottom-up technology
Online Access:https://www.mdpi.com/1999-4923/15/8/2037

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https://www.mdpi.com/1999-4923/15/8/2037

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