Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin
The curcumin degradation represents a significant limitation for its applications. The stability of free curcumin (FC) and immobilized curcumin in complex particles (ComPs) based on different polysaccharides was studied under the action of several factors. Ultraviolet-visible (UV-VIS) and Fourier-tr...
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3075 |
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| author | Camelia-Elena Iurciuc (Tincu) Leonard Ionuţ Atanase Christine Jérôme Vincent Sol Patrick Martin Marcel Popa Lăcrămioara Ochiuz |
| author_facet | Camelia-Elena Iurciuc (Tincu) Leonard Ionuţ Atanase Christine Jérôme Vincent Sol Patrick Martin Marcel Popa Lăcrămioara Ochiuz |
| author_sort | Camelia-Elena Iurciuc (Tincu) |
| collection | DOAJ |
| description | The curcumin degradation represents a significant limitation for its applications. The stability of free curcumin (FC) and immobilized curcumin in complex particles (ComPs) based on different polysaccharides was studied under the action of several factors. Ultraviolet-visible (UV-VIS) and Fourier-transform infrared (FTIR) spectroscopy proved the FC photodegradation and its role as a metal chelator: 82% of FC and between 26% and 39.79% of curcumin within the ComPs degraded after exposure for 28 days to natural light. The degradation half-life (t<sub>1/2</sub>) decreases for FC when the pH increases, from 6.8 h at pH = 3 to 2.1 h at pH = 9. For curcumin extracted from ComPs, t<sub>1/2</sub> was constant (between 10 and 13 h) and depended on the sample’s composition. The total phenol (TPC) and total flavonoids (TFC) content values increased by 16% and 13%, respectively, for FC exposed to ultraviolet light at λ = 365 nm (UVA), whereas no significant change was observed for immobilized curcumin. Antioxidant activity expressed by IC<sub>50</sub> (µmoles/mL) for FC exposed to UVA decreased by 29%, but curcumin within ComPs was not affected by the UVA. The bovine serum albumin (BSA) adsorption efficiency on the ComPs surface depends on the pH value and the cross-linking degree. ComPs have a protective role for the immobilized curcumin. |
| first_indexed | 2024-03-10T13:09:29Z |
| format | Article |
| id | doaj.art-341fc8f6245d480aac97459a3a268306 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:09:29Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-341fc8f6245d480aac97459a3a2683062023-11-21T10:52:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226307510.3390/ijms22063075Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized CurcuminCamelia-Elena Iurciuc (Tincu)0Leonard Ionuţ Atanase1Christine Jérôme2Vincent Sol3Patrick Martin4Marcel Popa5Lăcrămioara Ochiuz6Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 16 University Street, 700115 Iaşi, RomaniaDepartment of Biomaterials, Faculty of Dental Medicine, Apollonia University, 11 Pacurari Street, 700355 Iasi, RomaniaCenter for Education and Research on Macromolecules, CESAM-RU, University of Liège, Allée du 6 août 13, 4000 Liège, BelgiumLaboratoire PEIRENE EA 7500, University of Limoges, 87000 Limoges, FranceUniLaSalle, Unité Transformations & Agroressources, Université d’Artois, ULR7519, 62408 Béthune, FranceDepartment of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, Gheorghe Asachi Technical University, 73 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, RomaniaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 16 University Street, 700115 Iaşi, RomaniaThe curcumin degradation represents a significant limitation for its applications. The stability of free curcumin (FC) and immobilized curcumin in complex particles (ComPs) based on different polysaccharides was studied under the action of several factors. Ultraviolet-visible (UV-VIS) and Fourier-transform infrared (FTIR) spectroscopy proved the FC photodegradation and its role as a metal chelator: 82% of FC and between 26% and 39.79% of curcumin within the ComPs degraded after exposure for 28 days to natural light. The degradation half-life (t<sub>1/2</sub>) decreases for FC when the pH increases, from 6.8 h at pH = 3 to 2.1 h at pH = 9. For curcumin extracted from ComPs, t<sub>1/2</sub> was constant (between 10 and 13 h) and depended on the sample’s composition. The total phenol (TPC) and total flavonoids (TFC) content values increased by 16% and 13%, respectively, for FC exposed to ultraviolet light at λ = 365 nm (UVA), whereas no significant change was observed for immobilized curcumin. Antioxidant activity expressed by IC<sub>50</sub> (µmoles/mL) for FC exposed to UVA decreased by 29%, but curcumin within ComPs was not affected by the UVA. The bovine serum albumin (BSA) adsorption efficiency on the ComPs surface depends on the pH value and the cross-linking degree. ComPs have a protective role for the immobilized curcumin.https://www.mdpi.com/1422-0067/22/6/3075polysaccharides particlespolymeric matriximmobilized curcuminpH and light stabilitycurcumin metal complexesantioxidant activity |
| spellingShingle | Camelia-Elena Iurciuc (Tincu) Leonard Ionuţ Atanase Christine Jérôme Vincent Sol Patrick Martin Marcel Popa Lăcrămioara Ochiuz Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin International Journal of Molecular Sciences polysaccharides particles polymeric matrix immobilized curcumin pH and light stability curcumin metal complexes antioxidant activity |
| title | Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin |
| title_full | Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin |
| title_fullStr | Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin |
| title_full_unstemmed | Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin |
| title_short | Polysaccharides-Based Complex Particles’ Protective Role on the Stability and Bioactivity of Immobilized Curcumin |
| title_sort | polysaccharides based complex particles protective role on the stability and bioactivity of immobilized curcumin |
| topic | polysaccharides particles polymeric matrix immobilized curcumin pH and light stability curcumin metal complexes antioxidant activity |
| url | https://www.mdpi.com/1422-0067/22/6/3075 |
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