MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma

MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma

Abstract Background Metabolic reprogramming is a well-known marker of cancer, and it represents an early event during hepatocellular carcinoma (HCC) development. The recent approval of several molecular targeted agents has revolutionized the management of advanced HCC patients. Nevertheless, the lac...

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Main Authors: Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini, Claudio Stefanelli, Romana Fato, Laura Gramantieri, Francesca Fornari
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HCC
microRNA
miR-494
G6pc
Metabolism
Biomarker
Online Access:https://doi.org/10.1186/s13046-023-02718-w

Internet

https://doi.org/10.1186/s13046-023-02718-w

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