Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors.

Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors.

Dopa decarboxylase (DDC), a pyridoxal 5'-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson's disease (PD). PD is a neurodegenerative disease mainly due to a progressive loss of dopamine-producing cells in the midbrain. Co-administra...

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Bibliographic Details
Main Authors: Frederick Daidone, Riccardo Montioli, Alessandro Paiardini, Barbara Cellini, Antonio Macchiarulo, Giorgio Giardina, Francesco Bossa, Carla Borri Voltattorni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285636?pdf=render

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http://europepmc.org/articles/PMC3285636?pdf=render

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