TRPML1-Induced Lysosomal Ca<sup>2+</sup> Signals Activate AQP2 Translocation and Water Flux in Renal Collecting Duct Cells

TRPML1-Induced Lysosomal Ca<sup>2+</sup> Signals Activate AQP2 Translocation and Water Flux in Renal Collecting Duct Cells

Lysosomes are acidic Ca<sup>2+</sup> storage organelles that actively generate local Ca<sup>2+</sup> signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca<sup>2+</sup> signals in mouse renal collecting duct (CD) cells and w...

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Bibliographic Details
Main Authors: Simona Ida Scorza, Serena Milano, Ilenia Saponara, Maira Certini, Roberta De Zio, Maria Grazia Mola, Giuseppe Procino, Monica Carmosino, Francesco Moccia, Maria Svelto, Andrea Gerbino
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
aquaporin 2
lysosome
TRP channels
Ca<sup>2+</sup> signaling
nephron
collecting duct
Online Access:https://www.mdpi.com/1422-0067/24/2/1647

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https://www.mdpi.com/1422-0067/24/2/1647

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