ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma

ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma

ApoE plays an important role in lipoprotein metabolism. This study investigated the effects of adenovirus-mediated human apoE overexpression (AdhApoE3) on sterol metabolism and in vivo reverse cholesterol transport (RCT). In wild-type mice, AdhApoE3 resulted in decreased HDL cholesterol levels and a...

Full description

Bibliographic Details
Main Authors: Wijtske Annema, Arne Dikkers, Jan Freark de Boer, Thomas Gautier, Patrick C.N. Rensen, Daniel J. Rader, Uwe J.F. Tietge
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein E
reverse cholesterol transport
ATP-binding cassette transporter A1
atherosclerosis
bile
cholesteryl ester transfer protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520392233

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520392233

Similar Items