ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma

ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma

ApoE plays an important role in lipoprotein metabolism. This study investigated the effects of adenovirus-mediated human apoE overexpression (AdhApoE3) on sterol metabolism and in vivo reverse cholesterol transport (RCT). In wild-type mice, AdhApoE3 resulted in decreased HDL cholesterol levels and a...

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Bibliographic Details
Main Authors:	Wijtske Annema, Arne Dikkers, Jan Freark de Boer, Thomas Gautier, Patrick C.N. Rensen, Daniel J. Rader, Uwe J.F. Tietge
Format:	Article
Language:	English
Published:	Elsevier 2012-05-01
Series:	Journal of Lipid Research
Subjects:	apolipoprotein E reverse cholesterol transport ATP-binding cassette transporter A1 atherosclerosis bile cholesteryl ester transfer protein
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520392233

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