PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation

PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation

PKAN disease is caused by mutations in the PANK2 gene, encoding the mitochondrial enzyme pantothenate kinase 2, catalyzing the first and key reaction in Coenzyme A (CoA) biosynthetic process. This disorder is characterized by progressive neurodegeneration and excessive iron deposition in the brain....

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Bibliographic Details
Main Authors: Maddalena Ripamonti, Paolo Santambrogio, Gabriella Racchetti, Anna Cozzi, Ivano Di Meo, Valeria Tiranti, Sonia Levi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
PKAN disease
endosomal trafficking
cellular iron uptake
iron accumulation
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.878103/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.878103/full

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