Genomic Amplification of <i>UBQLN4</i> Is a Prognostic and Treatment Resistance Factor

Genomic Amplification of <i>UBQLN4</i> Is a Prognostic and Treatment Resistance Factor

Ubiquilin-4 (<i>UBQLN4</i>) is a proteasomal shuttle factor that directly binds to ubiquitylated proteins and delivers its cargo to the 26S proteasome for degradation. We previously showed that upregulated UBQLN4 determines the DNA damage response (DDR) through the degradation of MRE11A....

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Bibliographic Details
Main Authors: Yuta Kobayashi, Matias A. Bustos, Yoshiaki Shoji, Ron D. Jachimowicz, Yosef Shiloh, Dave S. B. Hoon
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
Ubiquilin-4
MRE11A
chemotherapy resistance
PARPi
genome amplification
prognosis
Online Access:https://www.mdpi.com/2073-4409/11/20/3311

Internet

https://www.mdpi.com/2073-4409/11/20/3311

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