NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma

NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma

Serine–threonine protein kinase B-RAF <b>(</b><i>BRAF)</i>-mutated metastatic melanoma (MM) is a highly aggressive type of skin cancer. Treatment of MM patients using BRAF/MEK inhibitors (BRAFi/MEKi) eventually leads to drug resistance, limiting any clinical benefit. Herein,...

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Bibliographic Details
Main Authors: Valentina Audrito, Vincenzo Gianluca Messana, Enrico Moiso, Nicoletta Vitale, Francesca Arruga, Lorenzo Brandimarte, Federica Gaudino, Elisa Pellegrino, Tiziana Vaisitti, Chiara Riganti, Roberto Piva, Silvia Deaglio
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
metastatic melanoma
BRAF inhibitors resistance
BRAF
metabolic reprogramming
NAD
NAMPT
Online Access:https://www.mdpi.com/2072-6694/12/12/3855

Internet

https://www.mdpi.com/2072-6694/12/12/3855

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