Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study

Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study

ObjectivesSignificant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole. To achieve target tacrolimus concentrations, an optimal dosage regimen i...

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Bibliographic Details
Main Authors: Yi-Chang Zhao, Zhi-Hua Sun, Jia-Kai Li, Huai-Yuan Liu, Bi-Kui Zhang, Xu-Biao Xie, Chun-Hua Fang, Indy Sandaradura, Feng-Hua Peng, Miao Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
population pharmacokinetics
voriconazole
renal transplantation
Monte Carlo simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1439232/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1439232/full

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