CD4+ T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS

CD4+ T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS

Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies predominantly against the acetylcholine receptor (AChR). Specific T cell subsets are required for long-term antibody responses, and cytokines secreted mainly from CD4+ T cells regulate B cell antibody production. The aim of t...

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Bibliographic Details
Main Authors: Merve Çebi, Hacer Durmus, Fikret Aysal, Berker Özkan, Gizem Engin Gül, Arman Çakar, Mehmet Hocaoglu, Metin Mercan, Sibel P. Yentür, Melih Tütüncü, Vildan Yayla, Onur Akan, Öner Dogan, Yeşim Parman, Güher Saruhan-Direskeneli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
T follicular helper cells
PD-1
ICOS
IL-21
IL-4
IL-17
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00809/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00809/full

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