Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers
Abstract Aim The ε4 allele of apolipoprotein E gene (APOE) is a well‐known risk factor of late‐onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12110 |
| _version_ | 1811301361689559040 |
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| author | Daimei Sasayama Kotaro Hattori Yuuki Yokota Ryo Matsumura Toshiya Teraishi Sumiko Yoshida Hiroshi Kunugi |
| author_facet | Daimei Sasayama Kotaro Hattori Yuuki Yokota Ryo Matsumura Toshiya Teraishi Sumiko Yoshida Hiroshi Kunugi |
| author_sort | Daimei Sasayama |
| collection | DOAJ |
| description | Abstract Aim The ε4 allele of apolipoprotein E gene (APOE) is a well‐known risk factor of late‐onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospinal fluid (CSF) protein levels. Methods The present study performed a secondary analysis on our previously generated database to compare the CSF levels of 1128 proteins between APOE‐ε4 carriers (28 subjects) and noncarriers (104 subjects). All subjects were physically healthy Japanese individuals without dementia. Results CSF levels of apoE2, apoE3, and apoE4 were significantly higher (all nominal P < 10 × 10−5, false discovery rate < 0.001) and those of tumor necrosis factor‐α (TNF‐α) were significantly lower (nominal P = 1.39 × 10−6, false discovery rate < 0.001) in APOE‐ε4 carriers than in noncarriers. No significant correlation was observed between the CSF levels of TNF‐α and any of the apoE proteins. Conclusions Our findings indicate the possible roles of apoE and TNF‐α in the pathogenesis of APOE‐ε4‐associated Alzheimer's disease. |
| first_indexed | 2024-04-13T07:07:31Z |
| format | Article |
| id | doaj.art-3436015ab27e4dae924d9cb1255bbddd |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-13T07:07:31Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-3436015ab27e4dae924d9cb1255bbddd2022-12-22T02:56:57ZengWileyNeuropsychopharmacology Reports2574-173X2020-06-0140220120510.1002/npr2.12110Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriersDaimei Sasayama0Kotaro Hattori1Yuuki Yokota2Ryo Matsumura3Toshiya Teraishi4Sumiko Yoshida5Hiroshi Kunugi6Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira JapanDepartment of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira JapanDepartment of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira JapanMedical Genome Center National Center of Neurology and Psychiatry Kodaira JapanDepartment of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira JapanMedical Genome Center National Center of Neurology and Psychiatry Kodaira JapanDepartment of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira JapanAbstract Aim The ε4 allele of apolipoprotein E gene (APOE) is a well‐known risk factor of late‐onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospinal fluid (CSF) protein levels. Methods The present study performed a secondary analysis on our previously generated database to compare the CSF levels of 1128 proteins between APOE‐ε4 carriers (28 subjects) and noncarriers (104 subjects). All subjects were physically healthy Japanese individuals without dementia. Results CSF levels of apoE2, apoE3, and apoE4 were significantly higher (all nominal P < 10 × 10−5, false discovery rate < 0.001) and those of tumor necrosis factor‐α (TNF‐α) were significantly lower (nominal P = 1.39 × 10−6, false discovery rate < 0.001) in APOE‐ε4 carriers than in noncarriers. No significant correlation was observed between the CSF levels of TNF‐α and any of the apoE proteins. Conclusions Our findings indicate the possible roles of apoE and TNF‐α in the pathogenesis of APOE‐ε4‐associated Alzheimer's disease.https://doi.org/10.1002/npr2.12110alzheimer diseaseapolipoproteins Ebiomarkerscerebrospinal fluid proteinstumor necrosis factor‐alpha |
| spellingShingle | Daimei Sasayama Kotaro Hattori Yuuki Yokota Ryo Matsumura Toshiya Teraishi Sumiko Yoshida Hiroshi Kunugi Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers Neuropsychopharmacology Reports alzheimer disease apolipoproteins E biomarkers cerebrospinal fluid proteins tumor necrosis factor‐alpha |
| title | Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers |
| title_full | Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers |
| title_fullStr | Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers |
| title_full_unstemmed | Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers |
| title_short | Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers |
| title_sort | increased apolipoprotein e and decreased tnf α in the cerebrospinal fluid of nondemented apoe ε4 carriers |
| topic | alzheimer disease apolipoproteins E biomarkers cerebrospinal fluid proteins tumor necrosis factor‐alpha |
| url | https://doi.org/10.1002/npr2.12110 |
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