Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018<sup>TM</sup> Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen

Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018<sup>TM</sup> Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen

Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are reports of enhanced adjuvanticity when the alum’s particle size is reduced to the nanometer range. Previously, we demonstrated that a recombinant...

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Bibliographic Details
Main Authors: Sakshi Bajoria, Ozan S. Kumru, Jennifer Doering, Katherine Berman, Greta Van Slyke, Anneka Prigodich, Sergio A. Rodriguez-Aponte, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Vaccines
Subjects:
nanoalum
CpG 1018
adjuvant
nanoparticle
vaccine
formulation
Online Access:https://www.mdpi.com/2076-393X/11/6/1030

Internet

https://www.mdpi.com/2076-393X/11/6/1030

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