Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

ABSTRACT Antibiotic tolerance within a biofilm community presents a serious public health challenge. Here, we report the identification of a 2-aminoimidazole derivative that inhibits biofilm formation by two pathogenic Gram-positive bacteria, Streptococcus mutans and Staphylococcus aureus. In S. mut...

Full description

Bibliographic Details
Main Authors: Chang Liu, Hua Zhang, Xian Peng, Meghan S. Blackledge, Robert E. Furlani, Haoting Li, Zhaoming Su, Roberta J. Melander, Christian Melander, Suzanne Michalek, Hui Wu
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
biofilms
response regulator
small molecule
virulence
Online Access:https://journals.asm.org/doi/10.1128/mbio.00137-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00137-23

Similar Items