Advances in Membrane-Bound Catechol-<i>O</i>-Methyltransferase Stability Achieved Using a New Ionic Liquid-Based Storage Formulation

Advances in Membrane-Bound Catechol-<i>O</i>-Methyltransferase Stability Achieved Using a New Ionic Liquid-Based Storage Formulation

Membrane-bound catechol-<i>O</i>-methyltransferase (MBCOMT), present in the brain and involved in the main pathway of the catechol neurotransmitter deactivation, is linked to several types of human dementia, which are relevant pharmacological targets for new potent and nontoxic inhibitor...

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Bibliographic Details
Main Authors: Ana M. Gonçalves, Ângela Sousa, Augusto Q. Pedro, Maria J. Romão, João A. Queiroz, Eugénia Gallardo, Luís A. Passarinha
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
membrane-bound catechol-<i>O</i>-methyltransferase
Design of Experiments
enzymatic activity
stability
ionic liquids
Online Access:https://www.mdpi.com/1422-0067/23/13/7264

Internet

https://www.mdpi.com/1422-0067/23/13/7264

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