Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Abstract Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists,...

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Bibliographic Details
Main Authors: Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Format: Article
Language:English
Published: Springer Nature 2019-10-01
Series:EMBO Molecular Medicine
Subjects:
BH3 mimetics
colon adenocarcinoma
electron transport chain
glioblastoma
LXR agonist
Online Access:https://doi.org/10.15252/emmm.201910769

Internet

https://doi.org/10.15252/emmm.201910769

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