Metformin alleviates crystalline silica-induced pulmonary fibrosis by remodeling endothelial cells to mesenchymal transition via autophagy signaling

Metformin alleviates crystalline silica-induced pulmonary fibrosis by remodeling endothelial cells to mesenchymal transition via autophagy signaling

Silicosis is a severe progressive lung disease without effective treatment methods. Previous evidence has demonstrated that endothelial cell to mesenchymal transition (EndoMT) plays an essential role in pulmonary fibrosis, and pulmonary fibrosis is associated with dysregulation of autophagy, while t...

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Bibliographic Details
Main Authors: Ning Li, Zhang Lin, Qiang Zhou, Meiyu Chang, Yongheng Wang, Yi Guan, Haibin Li, Yingzheng Zhao, Nan Liu, Yulan Jin, Sanqiao Yao
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Silicosis
Autophagy
Endothelial cell to mesenchymal transition
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132200940X

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http://www.sciencedirect.com/science/article/pii/S014765132200940X

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