<i>BRAF</i> and <i>MLH1</i> Analysis Algorithm for the Evaluation of Lynch Syndrome Risk in Colorectal Carcinoma Patients: Evidence-Based Data from the Analysis of 100 Consecutive Cases

<i>BRAF</i> and <i>MLH1</i> Analysis Algorithm for the Evaluation of Lynch Syndrome Risk in Colorectal Carcinoma Patients: Evidence-Based Data from the Analysis of 100 Consecutive Cases

Several causes may lead to CRC, either extrinsic (sporadic forms) or genetic (hereditary forms), such as Lynch syndrome (LS). Most sporadic deficient mismatch repair (dMMR) CRC cases are characterized by the methylation of the <i>MLH1</i> promoter gene and/or <i>BRAF</i> gene...

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Detalhes bibliográficos
Principais autores: Thais Maloberti, Antonio De Leo, Viviana Sanza, Lidia Merlo, Michela Visani, Giorgia Acquaviva, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Stefano Zagnoni, Daniela Turchetti, Sara Miccoli, Michelangelo Fiorentino, Antonietta D’Errico, Dario de Biase, Giovanni Tallini
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2022-06-01
coleção:Journal of Molecular Pathology
Assuntos:
<i>MLH1</i>
<i>BRAF</i>
colorectal cancer
Lynch syndrome
mismatch repair
microsatellite instability
Acesso em linha:https://www.mdpi.com/2673-5261/3/3/11

Internet

https://www.mdpi.com/2673-5261/3/3/11

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