Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis

Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis

Abstract Background Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also involved in the turnover of various regulatory proteins, antigen proces...

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Bibliographic Details
Main Authors: Hiroshi Maruyama, Kouichi Hirayama, Marina Yamashita, Kentaro Ohgi, Ryuji Tsujimoto, Mamiko Takayasu, Homare Shimohata, Masaki Kobayashi
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Rheumatology
Subjects:
ANCA-associated vasculitis
20S-proteasome
Disease activity
Microscopic polyangiitis
Proteasome
Online Access:http://link.springer.com/article/10.1186/s41927-020-00137-4

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http://link.springer.com/article/10.1186/s41927-020-00137-4

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