Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation

Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation

Abstract Neutrophil extracellular traps (NETs) has been demonstrated to regulate the metastasis of breast cancer. In this study, we showed that de novo cholesterol biosynthesis induced by ASPP2 depletion in mouse breast cancer cell 4T1 and human breast cancer cell MDA-MB-231 promoted NETs formation...

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Bibliographic Details
Main Authors: Qiqi Tang, Beibei Liang, Lisha Zhang, Xuhui Li, Hengyu Li, Wei Jing, Yingjie Jiang, Felix Zhou, Jian Zhang, Yanchun Meng, Xinhua Yang, Hao Yang, Gang Huang, Jian Zhao
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22410-x

Internet

https://doi.org/10.1038/s41598-022-22410-x

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