Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer’s Disease

Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer’s Disease

Phosphodiesterase 4 (PDE4)-dependent cAMP signaling plays a crucial role in cognitive impairment associated with Alzheimer’s disease (AD). However, whether inhibition of PDE4 subtypes or their splice variants in the prefrontal cortex positively regulates synaptic plasticity and antioxidative stress,...

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Bibliographic Details
Main Authors: Yongchuan Shi, Jinpeng Lv, Ling Chen, Guojun Luo, Mengjia Tao, Jianchun Pan, Xiaoxiong Hu, Jianwen Sheng, Shanjin Zhang, Min Zhou, Huizhen Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
PDE4D knockdown
cognitive deficits
synaptic failure
antioxidant-and antiapoptotic response
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.722580/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.722580/full

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