s-ketamine enhances thalamocortical and corticocortical synaptic transmission in acute murine brain slices via increased AMPA-receptor-mediated pathways

s-ketamine enhances thalamocortical and corticocortical synaptic transmission in acute murine brain slices via increased AMPA-receptor-mediated pathways

Despite ongoing research efforts and routine clinical use, the neuronal mechanisms underlying the anesthesia-induced loss of consciousness are still under debate. Unlike most anesthetics, ketamine increases thalamic and cortical activity. Ketamine is considered to act via a NMDA-receptor antagonism-...

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Bibliographic Details
Main Authors: Matthias Bieber, Stefan Schwerin, Matthias Kreuzer, Claudia Klug, Marie Henzler, Gerhard Schneider, Rainer Haseneder, Stephan Kratzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Systems Neuroscience
Subjects:
mechanisms of anesthesia
ketamine
thalamocortical
unconsciousness
patch-clamp
optogenetic
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2022.1044536/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsys.2022.1044536/full

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