The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis.

The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis.

Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase liberates highly potent circulating heparan sulfate-fragments (HS-fragments) and triggers the fatal and excessive inflammatory response in sepsis. As a potential anti-inflamma...

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Bibliographic Details
Main Authors: Lukas Martin, Rebecca De Santis, Patrick Koczera, Nadine Simons, Hajo Haase, Lena Heinbockel, Klaus Brandenburg, Gernot Marx, Tobias Schuerholz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4658182?pdf=render

Internet

http://europepmc.org/articles/PMC4658182?pdf=render

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