Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment. Hyperactivation of mTOR complex 1 (mTORC1) and subsequent impairment of the transcription factor EB (TFEB)-mediated autophagy–lysosomal p...

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Bibliographic Details
Main Authors: Xiliang Du, Chiara Di Malta, Zhiyuan Fang, Taiyu Shen, Xiaodi Niu, Meng Chen, Bo Jin, Hao Yu, Lin Lei, Wenwen Gao, Yuxiang Song, Zhe Wang, Chuang Xu, Zhijun Cao, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Autophagy
Fatty liver
Lotus leaf
Lysosome
MiT/TFE
mTORC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004846

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http://www.sciencedirect.com/science/article/pii/S2211383521004846

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