Protocatechuic aldehyde attenuates cisplatin-induced acute kidney injury by suppressing Nox-mediated oxidative stress and renal inflammation

Protocatechuic aldehyde attenuates cisplatin-induced acute kidney injury by suppressing Nox-mediated oxidative stress and renal inflammation

Cisplatin is a classic chemotherapeutic agent widely used to treat different types of cancers including ovarian, head and neck, testicular and uterine cervical carcinomas. However, cisplatin induces acute kidney injury by directly triggering an excessive inflammatory response, oxidative stress and p...

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Bibliographic Details
Main Authors: Li Gao, weifeng Wu, guiling Ren, haidi Li, qin Yang, xiaofeng Li, tao Xu, zeng Li, baoming Wu, taotao Ma, cheng Huang, dong Lei, yan Hang, lei Zhang, xiongwen Lv, Jun Li, Xiaoming Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Pharmacology
Subjects:
Acute Kidney Injury
Inflammation
Oxidative Stress
NOX4
necroptosis
Protocatechuic aldehyde
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00479/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00479/full

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