Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle
Abstract During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which is known to be activated by mitochondrial DNA (mtDNA) damage....
প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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বিন্যাস: | প্রবন্ধ |
ভাষা: | English |
প্রকাশিত: |
Nature Portfolio
2025-03-01
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মালা: | Nature Communications |
অনলাইন ব্যবহার করুন: | https://doi.org/10.1038/s41467-025-57299-3 |