Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6

Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6

Amyloidosis is a heterogeneous group of protein deposition diseases associated with the presence of amyloid fibrils in tissues. Analogs of insulin that are used for treating diabetic patients (including regular insulin) can form amyloid fibrils, both in vitro and in vivo as reported in patients. The...

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Bibliographic Details
Main Authors: Katia Azarfar, Parichehreh Yaghmaei, Mahsa M. Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
regular insulin
amyloidosis
aromatic compound
MMP2
TNF-α
IL-6
Online Access:https://www.mdpi.com/1422-0067/23/9/4952

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https://www.mdpi.com/1422-0067/23/9/4952

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