New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways

(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potency; (2) Methods: here, a new small compound library, endowed w...

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Bibliographic Details
Main Authors: Maria Grazia Signorello, Federica Rapetti, Elda Meta, Adama Sidibè, Olga Bruno, Chiara Brullo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
pyrazoles
imidazo-pyrazoles
medicinal chemistry
ROS inhibition
platelet aggregation inhibition
p38MAPK
Online Access:https://www.mdpi.com/1420-3049/26/19/5735

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https://www.mdpi.com/1420-3049/26/19/5735

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