Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jovéet al. describe structures of PatA from Mycobacterium smegmatisin complex with acyl donors and show that catalysis occurs by an unusual charge-relay mechanism.

Bibliographic Details
Main Authors: David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová, Marcelo E. Guerin
Format: Article
Language:English
Published: Nature Portfolio 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10906

Internet

https://doi.org/10.1038/ncomms10906

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