An Improved Method for P2X7R Antagonist Screening.

An Improved Method for P2X7R Antagonist Screening.

ATP physiologically activates the P2X7 receptor (P2X7R), a member of the P2X ionotropic receptor family. When activated by high concentrations of ATP (i.e., at inflammation sites), this receptor is capable of forming a pore that allows molecules of up to 900 Da to pass through. This receptor is upre...

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Bibliographic Details
Main Authors: Rômulo José Soares-Bezerra, Natiele Carla da Silva Ferreira, Anael Viana Pinto Alberto, André Gustavo Bonavita, Antônio Augusto Fidalgo-Neto, Andrea Surrage Calheiros, Valber da Silva Frutuoso, Luiz Anastacio Alves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4437783?pdf=render

Internet

http://europepmc.org/articles/PMC4437783?pdf=render

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