Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

The discovery of naturally occurring T cell receptors (TCRs) that confer specific, high-affinity recognition of pathogen and cancer-associated antigens remains a major goal in cellular immunotherapies. The contribution of the CD8 co-receptor to the interaction between the TCR and peptide-bound major...

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Bibliographic Details
Main Authors: Chad M. Williams, Alexandra A. Schonnesen, Shu-Qi Zhang, Ke-Yue Ma, Chenfeng He, Tori Yamamoto, S. Gail Eckhardt, Christopher A. Klebanoff, Ning Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
T cell receptor/pMHC interaction
two-dimensional affinity and kinetics
CD8 cooperation
CD8 binding independent T cell receptor
human viral-specific polyclonal CTL
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00894/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00894/full

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