Toward Stability Enhancement of NTS<sub>1</sub>R-Targeted Radioligands: Structural Interventions on [<sup>99m</sup>Tc]Tc-DT1

Toward Stability Enhancement of NTS<sub>1</sub>R-Targeted Radioligands: Structural Interventions on [<sup>99m</sup>Tc]Tc-DT1

The neurotensin subtype 1 receptor (NTS<sub>1</sub>R) is overexpressed in a number of human tumors, thereby representing a valid target for cancer theranostics with radiolabeled neurotensin (NT) analogs like [<sup>99m</sup>Tc]Tc-DT1 (DT1, N<sub>4</sub>-Gly<sup&...

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Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Berthold A. Nock, Eric P. Krenning, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
neurotensin subtype 1 receptor
radiolabeled neurotensin
targeted tumor imaging
Tc-99m
metabolic stability
neprilysin
Online Access:https://www.mdpi.com/1999-4923/15/8/2092

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https://www.mdpi.com/1999-4923/15/8/2092

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