Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response

Abstract Background Immune checkpoint blockade (ICB) therapies have changed the paradigm of cancer therapies. However, anti-tumor response of the ICB is insufficient for many patients and limited to specific tumor types. Despite many preclinical and clinical studies to understand the mechanism of an...

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Bibliographic Details
Main Authors: Yosuke Sato, Yu Fu, Hong Liu, Min Young Lee, Michael H. Shaw
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-021-08974-3