Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples

Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples

The development of lung fibrosis is a major concern in patients recovered from severe COVID-19 pneumonia. This study aimed to document the evolution of diffuse alveolar damage (DAD) to the fibrosing pattern and define the transcriptional programs involved. Morphological, immunohistochemical and tran...

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Bibliographic Details
Main Authors: Belén Pérez-Mies, Tamara Caniego-Casas, Tommaso Bardi, Irene Carretero-Barrio, Amparo Benito, Mónica García-Cosío, Irene González-García, David Pizarro, Marta Rosas, Eva Cristóbal, Yolanda Ruano, María Concepción Garrido, Juan Rigual-Bobillo, Raúl de Pablo, Juan Carlos Galán, David Pestaña, José Palacios
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
COVID-19
fibrosis
transcriptomic
diffuse alveolar damage (DAD)
autopsy
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.976759/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.976759/full

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