Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency

Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency

Abstract Background Premature ovarian insufficiency (POI) is an important cause of infertility characterized by the functional decline of the ovary. Granulosa cells (GCs) around oocytes are critical for folliculogenesis, and GC dysfunction is one of the important etiologies of POI. The aim of this s...

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Bibliographic Details
Main Authors: Dan Liu, Xiaohong Guan, Wenqiang Liu, Yanping Jia, Hong Zhou, Chenxiang Xi, Mei Zhao, Yuan Fang, Li Wu, Kunming Li
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Ovarian Research
Subjects:
RNA sequencing
Premature ovarian insufficiency
Granulosa cell
Weighted gene co-expression network analysis
UBE2C
Immune infiltration
Online Access:https://doi.org/10.1186/s13048-023-01266-3

Internet

https://doi.org/10.1186/s13048-023-01266-3

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