Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model

Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model

Abstract Background Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on epinephrine pharmacokinetics and heart rate changes...

Full description

Bibliographic Details
Main Authors: Richard Tuttle, Luca Popescu, Scott Hill, Amber Slanczka, Jeffrey Jankowski, Katherine Barre, Erika Krueger, Desmond Slade, Claire Croutch, Matthew Robben, Zack Mesa, Michael Mesa, Kenneth L. Dretchen
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Respiratory Research
Subjects:
Epinephrine
Nasal congestion
Histamine
Vasodilation
Intranasal
Severe allergy
Online Access:http://link.springer.com/article/10.1186/s12931-020-01343-x

Internet

http://link.springer.com/article/10.1186/s12931-020-01343-x

Similar Items